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MedChemexpress

货号: HY-13104

MRS 2578

  • 711019-86-2
  • C20H20N6S4
  • 98%
  • 7日

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  • MSDS
信息更新时间:2018.06.10
  • MRS 2578
  • 98%
  • 10mg
  • 1 mg
  • 7日
  • HY-13104
化合物信息 [查看化合物百科]
化合物英文学名 1-(3-isothiocyanatophenyl)-3-[4-[(3-isothiocyanatophenyl)carbamothioylamino]butyl]thiourea 化合物中文学名 MRS 2578
CAS号 711019-86-2 分子式 C20H20N6S4
分子量 472.673 精确质量 472.063
LogP 6.1362 PSA 201.2
外观与性状 白色固体 折射率 1.686
密度 1.31g/cm3 沸点 652.7ºC at 760 mmHg
闪点 348.5ºC
详细描述
产品描述:MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. IC50 value: 37 nM [1] Target: P2Y6 receptor in vitro: MRS2578 selectively blocks P2Y6 receptor activity versus activity at P2Y1, P2Y2, P2Y4 or P2Y11 receptors. MRS2578 (1 μM) completely blocks the protection by UDP undergoing TNFalpha-induced apoptosis in 1321N1 astrocytoma cells [1]. MRS 2578 inhibits basal NF-κB activity in time and dose dependent manner in HMEC-1 cells transfected with 0.25 μg NF-κB promoter reporter. MRS 2578 (10 μM) completely abolishes TNF-Alpha induced NF-κB reporter activity in HMEC-1 cells. MRS 2578 (10 μM) significant reduces TNF-Alpha–induced proinflammatory gene expression in HMEC-1 cells [2]. MRS2578-treated mice shows reduced bronchial hyperresponsiveness toward methacholine in OVA-sensitized mice. MRS2578 completely blocks UDP-induced the release of IL-6, KC, and IL-8 in lung epithelial cells [3]. in vivo: MRS 2578 (10 μM) attenuates Keratinocyte-derived chemokine serum protein levels in LPS-induced vascular inflammation in C57BL/6 mice [2]. MRS2578 (10 μM, intratracheally) reduces BALF eosinophilia and the levels of IL-5 and IL-13 in the BALF in OVA-sensitized mice and leads to a markedly attenuated change in methacholine responsiveness after OVA challenge. MRS2578 (10 μM, intratracheally) inhibits house dust mite–induced allergic airway inflammation in OVA-sensitized mice. MRS2578 (10 μM, intratracheally) reduces of IL-6 and KC levels in BALF in OVA-sensitized mice [4].
产品链接:http://www.medchemexpress.com/r788_prodrug-of-r406_.html
产品链接:http://www.medchemexpress.cn/mrs-2578.html

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MRS 2578

711019-86-2

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