货号： HY-15508

4-(4-羟基苯胺)-6,7-二甲氧基喹唑啉

CAS：202475-60-3
分子式：C16H15N3O3
纯度：98%
货期：7日

销售价 ￥949.00 /mg

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商家名称: MedChemexpress

所在地区: 美国新泽西纽瓦克

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化合物英文学名	Janex 1	化合物中文学名	4-(4-羟基苯胺)-6,7-二甲氧基喹唑啉
CAS号	202475-60-3	分子式	C16H15N3O3
分子量	297.309	精确质量	297.111
LogP	3.1692	PSA	76.5

产品描述:Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 78 μM); has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases. IC50 Value: 78 uM (JAK3)[1] Target: JAK3 in vitro: WHI-P131, which showed potent JAK3-inhibitory activity (IC50 of 78 microM), did not inhibit JAK1 and JAK2, the ZAP/SYK family tyrosine kinase SYK, the TEC family tyrosine kinase BTK, the SRC family tyrosine kinase LYN, or the receptor family tyrosine kinase insulin receptor kinase, even at concentrations as high as 350 microM. ANEX-1-pretreated islets showed resistance to cytokine toxicity, namely suppressed nitric oxide (NO) production, reduced inducible form of NO synthase (iNOS) expression, and decreased islet destruction. The molecular mechanism by which JANEX-1 inhibits iNOS expression was mediated through suppression of the nuclear factor kappaB (NF-kappaB) and JAK/signal transducer and activator of transcription (STAT) pathways [2]. The antigen-induced degranulation and activation of MAPKs were inhibited by WHI-P131 and WHI-P154 in both groups of BMMCs, indicating that these compounds inhibit a certain step except for Jak3. The antigen-induced increase in the activity of Fyn, a probable tyrosine kinase of Gab2, was also inhibited by WHI-P131 and WHI-P154 in RBL-2H3 cells [3]. in vivo: The incidence of diabetes at 25 weeks was only 9% for NOD females treated with daily injections of JANEX-1 (100 mg/kg/day) from Week 10 through Week 25 (P = 0.007). Furthermore, JANEX-1 prevented the development of insulitis and diabetes in NOD-scid/scid females after adoptive transfer of splenocytes from diabetic NOD females [4]. After intraperitoneal (i.p.) administration of two consecutive bolus doses of 25 mg/kg injected 30 min apart at dose level of 25 mg/kg, WHI-P131 was rapidly absorbed with an observed C(max) of 82.6 microM, which is higher than the target concentration of 30 microM, at which WHI-P131 abrogates mast cell responses in vitro and the time to reach the maximum plasma concentration (t(max)) was 10.0+/-2.9 min. At a nontoxic 50 mg/kg dose level, WHI-P131 prevented compound 48/80-induced mast cell histamine release and fatal anaphylaxis in mice [5]. Toxicity: N/A Clinical trial: N/A
产品链接:http://www.medchemexpress.com/CTEP.html
产品链接:http://www.medchemexpress.cn/janex-1.html

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产品名称: 4-(4-羟基苯胺)-6,7-二甲氧基喹唑啉

CAS号：: 202475-60-3

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4-(4’-羟基苯基)氨基-6,7-二甲氧基喹唑啉	98%	1g	中国,河南	1日	郑州杰克斯化工产品有限公司	价格需洽谈	查看详情
4-(4'-羟基苯基)氨基-6,7-二甲氧基喹唑啉	99	1kg	中国,湖南	3日	金锦乐（湖南）化学有限公司	价格需洽谈	查看详情
4-(4-羟基苯胺)-6,7-二甲氧基喹唑啉	98%	10mg、25mg 等3种	美国,马萨诸塞	1日	TARGET MOLECULE CORP.	¥ 3324 起	查看详情
4-(4-羟基苯胺)-6,7-二甲氧基喹唑啉	85%	50g、10g 等4种	中国,北京	7日	北京安必奇生物科技有限公司	价格需洽谈	查看详情
4-(4-羟基苯胺)-6,7-二甲氧基喹唑啉	95+%	1g	美国,伊利诺斯	10日	ARK PHARM INC	¥ 4170 起	查看详情
4-(4-羟基苯胺)-6,7-二甲氧基喹唑啉	98%	5mg、10mg 等3种	中国,上海	3日	上海伟寰生物科技有限公司	¥ 6840 起	查看详情
WHI-P131	98%	5mg	中国,江苏	现货	无锡东禾医药科技有限公司	¥ 500 起	查看详情
4-(4-羟基苯胺)-6,7-二甲氧基喹唑啉	98%	10mg	中国,四川	21日	成都思天德生物科技有限公司	价格需洽谈	查看详情
4-(4-羟基苯胺)-6,7-二甲氧基喹唑啉	98%+	1kg、1ton 等3种	中国,吉林	7日	长春三邦医药科技有限公司	价格需洽谈	查看详情
Janex 1	96%	100g、10g 等3种	美国,爱达荷	7日	American Custom Chemicals Corporation	价格需洽谈	查看详情