货号： HY-14445

N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide

CAS：116686-15-8
分子式：C15H13F2NO4S
纯度：98%
货期：7日

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商家名称: MedChemexpress

所在地区: 美国新泽西纽瓦克

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化合物英文学名	N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide	化合物中文学名	N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺
CAS号	116686-15-8	分子式	C15H13F2NO4S
分子量	341.33	精确质量	341.053
LogP	4.485	PSA	80.85
折射率	1.578	蒸汽压	1.21E-07mmHg at 25°C
密度	1.419g/cm3	沸点	431.3ºC at 760mmHg
闪点	214.6ºC

产品描述:FK 3311 is a selective inhibitor of COX-2; antiinflammatory agent. IC50 Value: 1.6 uM [1] Target: COX-2 Cyclooxygenase (COX) is an intracellular enzyme that converts arachidonic acid into prostaglandin (PG)G2 and PGH2. in vitro: The racemic mixtures and the (R)- and (S)-isomers of the 2 metabolites were inactive in the PGE2 test. IC50 values were more than 100 uM for (2 and 5), compared to 1.6 uM for FK-3311. Antiinflammatory activity was assessed by inhibition of adjuvant-induced arthritis, and analgesic activity was determined in the acetic acid-induced writhing assay. Following p.o. administration of 10 mg/kg, racemic (2) and its optical isomers showed activity comparable to FK-3311 (76% inhibition) in the adjuvant arthritis test, whereas racemic (5) showed very weak activity, and (R)- and (S)-(5) were not tested. With regard to analgesic effects, FK-3311 and racemic (2) showed 81 and 62% inhibitions, respectively, at a dose of 100 mg/kg p.o. The (R)- and (S)-isomers of (2) and racemic (5) all showed 46% inhibition of writhing syndrome. (R)- and (S)-(5) were less active showing 16 and 20% inhibitions, respectively[1]. in vivo: L-PVR, CO, PaO(2), and WDR were significantly (P < 0.05) better in the FK group than in the control group. Histological tissue edema was mild, and PMN infiltration was significantly (P < 0.05) reduced in the FK group compared to the control group. The serum TxB(2) levels were significantly (P < 0.05) lower in the FK group than in the control group, while 6-keto-PGF(1alpha) levels were not significantly (P < 0.05) reduced. Two-day survival rate was significantly (P < 0.05) better in the FK group than in the control group [2]. Survival rate was significantly better (p <. 05) and serum GOT levels 30 min after reperfusion were significantly lower (p <. 05) in the FK high-dose group compared to the other two groups. Four hours after reperfusion, GPT levels and liver tissue flow were significantly (p <. 05) better in the FK high-dose group compared to the control. Both 30 min and 4 hr after reperfusion, serum TxB(2) levels were significantly lower in the FK high-dose group compared to the control (p <. 05) [3].
产品链接:http://www.medchemexpress.com/nilvadipine.html
产品链接:http://www.medchemexpress.cn/fk-3311.html

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产品名称: N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide

CAS号：: 116686-15-8

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产品名称	纯度	规格	地区	货期	公司名称	参考	操作
FK 3311	98%	10mg、50mg	中国,上海	3日	上海伟寰生物科技有限公司	¥ 5604 起	查看详情
FK3311	98%	5mg	中国,江苏	现货	无锡东禾医药科技有限公司	¥ 500 起	查看详情
N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide	98%	10mg	中国,四川	7日	成都思天德生物科技有限公司	价格需洽谈	查看详情
N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide	96%	100g、500g 等3种	美国,爱达荷	7日	American Custom Chemicals Corporation	价格需洽谈	查看详情
N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide	95%	5g、25g	中国,浙江	7日	杭州沙力医药科技有限公司	价格需洽谈	查看详情
N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide	98%	10g	中国,上海	7日	上海兰浚生物科技有限公司	价格需洽谈	查看详情
N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide	98%	50mg	中国,上海	7日	上海比希化工有限公司	价格需洽谈	查看详情